ORGANOMETALLIC CHEMISTRY

Strained boronates do the trick

Strained boronate complexes have now been shown to enable an unprecedented cross-coupling reaction across a C–C σ-bond. Using this approach, highly functionalized cyclobutanes can be prepared with excellent stereocontrol from readily available reagents.

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Fig. 1: Comparison between the conjunctive cross-coupling as described by Morken and the carbopalladation of strained σ-bonds as reported by Aggarwal.

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Correspondence to Mariola Tortosa.

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Parra, A., Tortosa, M. Strained boronates do the trick. Nature Chem 11, 104–106 (2019). https://doi.org/10.1038/s41557-018-0202-9

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