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ANTIBIOTICS

A positive positive to negative

Nature Chemistryvolume 10pages9981000 (2018) | Download Citation

The structure of an antibiotic that is effective against Gram-positive bacteria, but not against Gram-negative bacteria, has now been modified to improve its effectiveness against Gram-negative bacteria. The approach could help broaden the spectrum of activity of other antibiotics.

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Author information

Affiliations

  1. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA

    • Jed F. Fisher
    •  & Shahriar Mobashery

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Correspondence to Shahriar Mobashery.

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DOI

https://doi.org/10.1038/s41557-018-0148-y

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