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SYNTHETIC METHODOLOGY

Easy as one, two, three

The preparation of three-dimensional frameworks with multiple stereocentres from simple acyclic hydrocarbons represents a challenging transformation. Now, starting from simple and readily available reagents, formation of these complex targets can be achieved in just three catalytic transformations with high levels of stereocontrol.

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Fig. 1: The stereoselective preparation of acyclic hydrocarbon motifs, featuring up to four contiguous stereogenic elements, from readily available reagents.

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Correspondence to Vittorio Pace.

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Castoldi, L., Pace, V. Easy as one, two, three. Nature Chem 10, 1081–1082 (2018). https://doi.org/10.1038/s41557-018-0139-z

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