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Easy as one, two, three

The preparation of three-dimensional frameworks with multiple stereocentres from simple acyclic hydrocarbons represents a challenging transformation. Now, starting from simple and readily available reagents, formation of these complex targets can be achieved in just three catalytic transformations with high levels of stereocontrol.

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  1. 1.

    Gaich, T. & Baran, P. S. J. Org. Chem. 75, 4657–4673 (2010).

  2. 2.

    Marek, I. et al. J. Am. Chem. Soc. 136, 2682–2694 (2014).

  3. 3.

    Bruffaerts, J., Pierrot, D. & Marek, I. Nat. Chem. (2018).

  4. 4.

    Burns, M. et al. Nature 513, 183–188 (2014).

  5. 5.

    Singh, S., Bruffaerts, J., Vasseur, A. & Marek, I. Nat. Commun. 8, 14200 (2017).

  6. 6.

    Vasseur, A., Bruffaerts, J. & Marek, I. Nat. Chem. 8, 209–219 (2016).

  7. 7.

    Mei, T.-S., Werner, E. W., Burckle, A. J. & Sigman, M. S. J. Am. Chem. Soc. 135, 6830–6833 (2013).

  8. 8.

    Mei, T.-S., Patel, H. H. & Sigman, M. S. Nature 508, 340–344 (2014).

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Correspondence to Vittorio Pace.

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Fig. 1: The stereoselective preparation of acyclic hydrocarbon motifs, featuring up to four contiguous stereogenic elements, from readily available reagents.