Knots have been rigorously studied since the 1860s, but only in the past 30 years have they been made in the laboratory in molecular form. Now, the most complex small-molecule examples so far — a composite knot and an isomeric link, each with nine crossings — have been prepared.
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Fenlon, E.E. What tangled webs we weave. Nature Chem 10, 1078–1079 (2018). https://doi.org/10.1038/s41557-018-0135-3
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DOI: https://doi.org/10.1038/s41557-018-0135-3
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