MOLECULAR TOPOLOGY

What tangled webs we weave

Knots have been rigorously studied since the 1860s, but only in the past 30 years have they been made in the laboratory in molecular form. Now, the most complex small-molecule examples so far — a composite knot and an isomeric link, each with nine crossings — have been prepared.

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Fig. 1: Molecular knots and links that have been synthesized.

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Correspondence to Edward E. Fenlon.

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Fenlon, E.E. What tangled webs we weave. Nature Chem 10, 1078–1079 (2018). https://doi.org/10.1038/s41557-018-0135-3

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