GLYCOSYLATION

Hitting the sweet spot

As the most abundant class of biomolecules on Earth, carbohydrates are implicated in a multitude of biological functions. Now, a simple chemical transformation has enabled the direct and selective installation of carbohydrates onto a diverse range of small molecules and peptides.

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Fig. 1: Comparison of methods for glycosylation.

Figure adapted from ref. 4, Macmillan Publishers Ltd.

References

  1. 1.

    Lauc, G., Krištić, J. & Zoldoš, V. Front. Genet. 5, 145 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. 2.

    Doores, K. J., Gamblin, D. P. & Davis, B. G. Chem. Eur. J. 12, 656–665 (2006).

    Article  CAS  PubMed  Google Scholar 

  3. 3.

    Moradi, S. V., Hussein, W. M., Varamini, P., Simerska, P. & Toth, I. Chem. Sci. 7, 2492–2500 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Wadzinski, T. J. et al. Nat. Chem. https://doi.org/10.1038/s41557-018-0041-8 (2018).

  5. 5.

    Lafite, P. & Daniellou, R. Nat. Prod. Rep. 29, 729–738 (2012).

    Article  CAS  PubMed  Google Scholar 

  6. 6.

    Pelletier, G., Zwicker, A., Allen, C. L., Schepartz, A. & Miller, S. J. J. Am. Chem. Soc. 138, 3175–3182 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. 7.

    deGruyter, J. N., Malins, L. R. & Baran, P. S. Biochemistry 56, 3863–3873 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Lara R. Malins.

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Malins, L.R. Hitting the sweet spot. Nature Chem 10, 578–580 (2018). https://doi.org/10.1038/s41557-018-0071-2

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