Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

GLYCOSYLATION

Hitting the sweet spot

As the most abundant class of biomolecules on Earth, carbohydrates are implicated in a multitude of biological functions. Now, a simple chemical transformation has enabled the direct and selective installation of carbohydrates onto a diverse range of small molecules and peptides.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Comparison of methods for glycosylation.

Figure adapted from ref. 4, Macmillan Publishers Ltd.

References

  1. 1.

    Lauc, G., Krištić, J. & Zoldoš, V. Front. Genet. 5, 145 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. 2.

    Doores, K. J., Gamblin, D. P. & Davis, B. G. Chem. Eur. J. 12, 656–665 (2006).

    Article  CAS  PubMed  Google Scholar 

  3. 3.

    Moradi, S. V., Hussein, W. M., Varamini, P., Simerska, P. & Toth, I. Chem. Sci. 7, 2492–2500 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Wadzinski, T. J. et al. Nat. Chem. https://doi.org/10.1038/s41557-018-0041-8 (2018).

  5. 5.

    Lafite, P. & Daniellou, R. Nat. Prod. Rep. 29, 729–738 (2012).

    Article  CAS  PubMed  Google Scholar 

  6. 6.

    Pelletier, G., Zwicker, A., Allen, C. L., Schepartz, A. & Miller, S. J. J. Am. Chem. Soc. 138, 3175–3182 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. 7.

    deGruyter, J. N., Malins, L. R. & Baran, P. S. Biochemistry 56, 3863–3873 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Lara R. Malins.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Malins, L.R. Hitting the sweet spot. Nature Chem 10, 578–580 (2018). https://doi.org/10.1038/s41557-018-0071-2

Download citation

Search

Quick links