Bruce C. Gibb discusses the biochemistry behind the sensory experiences associated with eating chillies and the lesser-known tingle-inducing ‘sanshools’.
This is a preview of subscription content, access via your institution
Access options
Subscribe to Nature+
Get immediate online access to Nature and 55 other Nature journal
$29.99
monthly
Subscribe to Journal
Get full journal access for 1 year
$119.00
only $9.92 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Buy article
Get time limited or full article access on ReadCube.
$32.00
All prices are NET prices.

References
Wender, P. A. et al. J. Am. Chem. Soc. 119, 12976–12977 (1997).
Hashimoto, S., Katoh, S. I., Kato, T., Urabe, D. & Inoue, M. J. Am. Chem. Soc. 139, 16420–16429 (2017).
Zasshi, Y. Yakugaku Zasshi 51, 384–390 (1931).
Jacobson, M. J. Am. Chem. Soc. 70, 4234–4237 (1948).
Crombie, L. J. Chem. Soc. 2997–3008 (1952).
Crombie, L. J. Chem. Soc. 995–998 (1955).
Bryant, B. P. & Mezine, I. Brain Res. 842, 452–460 (1999).
Sugai, E. et al. Biosci. Biotechnol. Biochem. 69, 1951–1957 (2005).
Koo, J. Y. et al. Eur. J. Neurosci. 26, 1139–1147 (2007).
Lennertz, R. C., Tsunozaki, M., Bautista, D. M. & Stucky, C. L. J. Neurosci. 30, 4353–4361 (2010).
Gerhold, K. A. & Bautista, D. M. Ann. N. Y. Acad. Sci 1170, 184–189 (2009).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gibb, B.C. Tweaking mechanosensors. Nature Chem 10, 483–484 (2018). https://doi.org/10.1038/s41557-018-0051-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41557-018-0051-6