Ribosomes have now been shown to accept certain initiator tRNAs acylated with aromatic foldamer–dipeptides thereby enabling the translation of a peptide or protein with a short aromatic foldamer at the N-terminus. Some foldamer–peptide hybrids could be cyclized to generate macrocycles that present conformationally restricted peptide loops.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Change history
10 July 2018
In the News & Views ‘Foldamers wave to the ribosome’, multiple changes to the main text were required. In paragraph 2 “whose monomer sequence is truly defined” should have read “whose monomer sequence is both diverse and truly defined” and “Truly sequence-defined...” should have read “Diverse and truly sequence defined…”. In the penultimate paragraph, ‘appendages 5–9’ should have been “appendages 5 and 7–9”; in the sentence starting “Based on these criteria...”, QPQ should have been QQQ and vice versa; and the whole sentence starting “What is interesting...” needed revising to “What is interesting is that an alternating sequence with a terminal P monomer appears essential: PQPQ is unfolded and an initiator tRNA carrying PQPQ–Gly–Phe initiates translation, whereas QPQPQ is folded and does not.” Furthermore, the structures in Fig. 1a have been replaced to correct several errors in the chemical structures arising from missing –CH2– groups. The table in Fig. 1b also required changes: in the last two columns of row two, ‘Fast’ and ‘No’ should have read ‘Slow and ‘Yes’, respectively; in the first column of row three, ‘ND’ should have been a tick; and in the last two columns of row four, ‘Slow’ and ‘Yes’ should have read ‘Fast’ and ‘No’, respectively. Finally, a new reference ‘Milon, P. et al. EMBO Rep. 11, 312–316 (2010).’ has been added to the reference list at number 13 and cited in the fifth paragraph, the references list has been renumbered accordingly.
References
Petersson, E. J. & Schepartz, A. J. Am. Chem. Soc. 130, 821 (2008).
Niu, J., Hili, R. & Liu, D. R. Nat. Chem. 5, 282–292 (2013).
De, Bo,G. et al. J. Am. Chem. Soc. 139, 10875–10879 (2017).
Guo, J. T., Wang, J. Y., Anderson, J. C. & Schultz, P. G. Angew. Chem. Int. Ed. 47, 722–725 (2008).
Xiao, H. & Schultz, P. G. Cold Spring Harbor Perspect. Biol. 8, 18 (2016).
Obexer, R., Walport, L. J. & Suga, H. Curr. Opin. Chem. Biol. 38, 52–61 (2017).
Maini, R. et al. Bioorganic Med. Chem. 21, 1088–1096 (2013).
Czekster, C. M., Robertson, W. E., Walker, A. S., Soll, D. & Schepartz, A. J. Am. Chem. Soc. 138, 5194–5197 (2016).
Huc, I. et al. Nat. Chem. https://doi.org/10.1038/s41557-018-0007-x (2018).
Torikai, K. & Suga, H. J. Am. Chem. Soc. 136, 17359–17361 (2014).
Verdine, G. L. & Hilinski, G. J. in Methods in Enzymology: Protein Engineering for Therapeutics Vol. 503 (eds Wittrup, K. D. & Verdine, G. L.) 3–33 (Academic, 2012).
Wu, H. et al. ChemBioChem https://doi.org/10.1002/cbic.201800026 (2018).
Milon, P. et al. EMBO Rep. 11, 312–316 (2010).
Hunter, P. et al. Molec. Cell 68, 515 (2017).
Huang, P.-Y, et al. Preprint at https://www.biorxiv.org/content/early/2017/04/10/125930 (2017).
Kramer, G., Boehringer, D., Ban, N. & Bukau, B. Nat. Struct. Molec. Biol. 16, 589–597 (2009).
Nakatogawa, H. & Ito, K. Cell 108, 629–636 (2002).
Orelle, C. et al. Nature 524, 119–124 (2015).
Fried, S. D., Schmied, W. H., Uttamapinant, C. & Chin, J. W. Angew. Chem. Int. Ed. 54, 12791–12794 (2015).
Lajoie, M. J. et al. Science 342, 357–360 (2013).
Zhang, Y. et al. Nature 551, 644–647 (2017)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Schepartz, A. Foldamers wave to the ribosome. Nature Chem 10, 377–379 (2018). https://doi.org/10.1038/s41557-018-0036-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41557-018-0036-5
