Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

SYNTHETIC BIOLOGY

Made in translation

Evolution of highly functionalized DNA could enable the discovery of artificial nucleic acid sequences with different properties to natural DNA. Now, an artificial translation system has been designed that can support the evolution of non-natural sequence-defined nucleic acid polymers carrying eight different functional groups on 32 codons.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: In vitro translation of non-natural sequence-defined nucleic acid polymers.

References

  1. 1.

    Dunn, M. R., Jimenez, R. M. & Chaput, J. C. Nat. Rev. Chem. 1, 0076 (2017).

    Article  CAS  Google Scholar 

  2. 2.

    Wilson, D. S. & Szostak, J. W. Ann. Rev. Biochem. 68, 611–647 (1999).

    Article  CAS  PubMed  Google Scholar 

  3. 3.

    Joyce, G. F. Ann. Rev. Biochem. 73, 791–836 (2004).

    Article  CAS  PubMed  Google Scholar 

  4. 4.

    Pinheiro, V. B. et al. Science 336, 341–344 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Joyce, G. F. Cold Spring Harb. Symp. Quant. Biol. 52, 41–51 (1987).

    Article  CAS  PubMed  Google Scholar 

  6. 6.

    Chen, Z., Lichtor, P. A., Berliner, A. P., Chen, J. C. & Liu, D. R. Nat. Chem. https://doi.org/10.1038/s41557-018-0008-9 (2018).

  7. 7.

    Kong, D., Yeung, W. & Hili, R. J. Am. Chem. Soc. 139, 13977–13980 (2017).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to John C. Chaput.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Chaput, J.C. Made in translation. Nature Chem 10, 379–381 (2018). https://doi.org/10.1038/s41557-018-0034-7

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing