SYNTHETIC BIOLOGY

Made in translation

Evolution of highly functionalized DNA could enable the discovery of artificial nucleic acid sequences with different properties to natural DNA. Now, an artificial translation system has been designed that can support the evolution of non-natural sequence-defined nucleic acid polymers carrying eight different functional groups on 32 codons.

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Fig. 1: In vitro translation of non-natural sequence-defined nucleic acid polymers.

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Correspondence to John C. Chaput.

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Chaput, J.C. Made in translation. Nature Chem 10, 379–381 (2018). https://doi.org/10.1038/s41557-018-0034-7

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