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SYNTHETIC BIOLOGY

Made in translation

Nature Chemistry volume 10, pages 379–381 (2018)Cite this article

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Evolution of highly functionalized DNA could enable the discovery of artificial nucleic acid sequences with different properties to natural DNA. Now, an artificial translation system has been designed that can support the evolution of non-natural sequence-defined nucleic acid polymers carrying eight different functional groups on 32 codons.

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Fig. 1: In vitro translation of non-natural sequence-defined nucleic acid polymers.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Department of Chemistry, and the Department of Molecular Biology & Biochemistry, University of California, Irvine, CA, USA

    John C. Chaput

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  1. John C. Chaput
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Correspondence to John C. Chaput.

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Chaput, J.C. Made in translation. Nature Chem 10, 379–381 (2018). https://doi.org/10.1038/s41557-018-0034-7

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