Autophagy decreases with age, and this is in part attributed to increasing levels of the autophagy-suppressing protein Rubicon. Cell biologists now find another ageing-associated function for Rubicon — the release of exosomes containing microRNAs that control senescence and longevity.
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References
Klionsky, D. J. et al. EMBO J. 40, e108863 (2021).
Nakamura, S. et al. Nat. Commun. 10, 847 (2019).
Matsunaga, K. et al. Nat. Cell Biol. 11, 385–396 (2009).
Tabata, K. et al. Mol. Biol. Cell 21, 4162–4172 (2010).
Xu, D. & Tahara, H. Adv. Drug Deliv. Rev. 65, 368–375 (2013).
Yanagawa, K. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01481-0 (2024).
Vietri, M., Radulovic, M. & Stenmark, H. Nat. Rev. Mol. Cell Biol. 21, 25–42 (2020).
Mensa, E. et al. J. Extracell. Vesicles 9, 1725285 (2020).
Dooley, H. C. et al. Mol. Cell 55, 238–252 (2014).
Raiborg, C. et al. J. Cell Sci. 114, 2255–2263 (2001).
Yamamuro, T. et al. Nat. Commun. 11, 4150 (2020).
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Zhen, Y., Stenmark, H. Exosome regulation by Rubicon in ageing. Nat Cell Biol 26, 1380–1381 (2024). https://doi.org/10.1038/s41556-024-01482-z
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DOI: https://doi.org/10.1038/s41556-024-01482-z
