Using single-cell RNA sequencing analysis of bone-colonizing tumour cells and in vivo screening, lymphotoxin-β (LTβ) was identified as a key factor promoting bone colonization and outgrowth of breast cancer metastases. Blocking LTβ signalling significantly suppressed bone metastasis, highlighting its potential as a therapeutic target for breast cancer with bone metastatic disease.
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References
Sosa, M. S., Bragado, P. & Aguirre-Ghiso, J. A. Mechanisms of disseminated cancer cell dormancy: an awakening field. Nat. Rev. Cancer 14, 611–622 (2014). A review article that presents mechanisms of tumour cell dormancy and strategies to target minimal residual disease to prevent metastasis.
Satcher, R. L. & Zhang, X. H. Evolving cancer-niche interactions and therapeutic targets during bone metastasis. Nat. Rev. Cancer 22, 85–101 (2022). A review article that presents a summary of the effect of the bone microenvironment on metastasis.
Kang, Y. et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3, 537–549 (2003). This paper reports the identification and validation of genes responsible for osteolytic bone metastasis in breast cancer cells.
Wang, H. et al. The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells. Cancer Cell 27, 193–210 (2015). This paper reports the interaction between osteoblasts and cancer cells in bone colonization.
Lu, X. et al. VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging alpha4beta1-positive osteoclast progenitors. Cancer Cell 20, 701–714 (2011). This paper reports the role of VCAM1 in metastatic recurrence after dormancy in bone metastasis.
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This is a summary of: Wang, X. et al. Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01478-9 (2024).
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The dual roles of lymphotoxin-β in promoting breast cancer bone metastasis. Nat Cell Biol 26, 1384–1385 (2024). https://doi.org/10.1038/s41556-024-01479-8
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DOI: https://doi.org/10.1038/s41556-024-01479-8
