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Phase separation

Unfolding emergency calls stress granules to the ER

Sensing stress within the endoplasmic reticulum (ER), the ER transmembrane protein IRE1α initiates a signal transduction pathway to restore homeostasis. A study finds that this process requires an ER membrane-bound phase separation event that leads to the local assembly of stress granules (SGs) and delivery of signalling components.

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Fig. 1: Nexus of the UPR and ISR: IRE1α co-condenses with SGs.

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Correspondence to David Pincus or Scott A. Oakes.

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S.A.O. is a co-founder, equity holder and consultant for OptiKIRA, LLC. D.P. declares no competing interests.

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Pincus, D., Oakes, S.A. Unfolding emergency calls stress granules to the ER. Nat Cell Biol 26, 845–846 (2024). https://doi.org/10.1038/s41556-024-01434-7

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