Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer

Translational control by VARS in melanoma

Aminoacyl-tRNA synthetases can promote or suppress cancer progression by regulating codon-dependent translation. A study now shows that valine aminoacyl-tRNA synthetase (VARS) promotes therapeutic resistance of melanoma to MAPK pathway inhibitors by enhancing translation of valine-enriched genes, including the fatty acid oxidation gene HADH.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Increased VARS contributes to melanoma resistance against MAPK pathway inhibitor therapy.

References

  1. Mansoori, B., Mohammadi, A., Davudian, S., Shirjang, S. & Baradaran, B. Adv. Pharm. Bull. 7, 339–348 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Robichaud, N., Sonenberg, N., Ruggero, D. & Schneider, R. J. Cold Spring Harb. Perspect. Biol. 11, a032896 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Hayes, J., Peruzzi, P. P. & Lawler, S. Trends Mol. Med. 20, 460–469 (2014).

    Article  CAS  PubMed  Google Scholar 

  4. Earnest-Noble, L. B. et al. Nat. Cancer 3, 1484–1497 (2022).

    Article  CAS  PubMed  Google Scholar 

  5. Huh, D. et al. EMBO J. 40, e106696 (2021).

    Article  CAS  PubMed  Google Scholar 

  6. Barbieri, I. & Kouzarides, T. Nat. Rev. Cancer 20, 303–322 (2020).

    Article  CAS  PubMed  Google Scholar 

  7. Kwon, N. H., Fox, P. L. & Kim, S. Nat. Rev. Drug Discov. 18, 629–650 (2019).

    Article  CAS  PubMed  Google Scholar 

  8. Passarelli, M. C. et al. Nat. Cell Biol. 24, 307–315 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Thandapani, P. et al. Nature 601, 428–433 (2022).

    Article  CAS  PubMed  Google Scholar 

  10. El-Hachem, N. et al. Nature Cell Biology https://doi.org/10.1038/s41556-024-1439-2 (2024).

    Article  Google Scholar 

  11. Aloia, A. et al. Clin. Cancer Res. 25, 6852–6867 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Braicu, C. et al. Cancers 11, 1618 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Hsu, D. J. et al. Sci. Adv. 9, eade9120 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

Q.W. has been awarded National Institutes of Health grant NCI K00CA253719. S.F.T. is supported by grants from the National Cancer Institute of the National Institutes of Health under award numbers R35CA274446 and U54CA261701 and the Black Family Metastasis Center.

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Qiushuang Wu or Sohail F. Tavazoie.

Ethics declarations

Competing interests

S.F.T. is a cofounder, shareholder and member of the scientific advisory board of Inspirna. Q.W. declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wu, Q., Tavazoie, S.F. Translational control by VARS in melanoma. Nat Cell Biol (2024). https://doi.org/10.1038/s41556-024-01430-x

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41556-024-01430-x

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing