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Cells dispose of cytoplasmic mitochondrial DNA by nucleoid-phagy

Mitochondrial damage in stress conditions results in the release of mitochondrial DNA (mtDNA), causing inflammation that is linked to various diseases. We discovered a mechanism for the elimination of this harmful mtDNA — ‘nucleoid-phagy’. Targeting this process represents another way to treat mitochondrial damage-related diseases.

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Fig. 1: TFAM is an autophagy receptor for cytoplasmic mtDNA.


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This is a summary of: Liu, H. et al. TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA. Nat. Cell. Biol. (2024).

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Cells dispose of cytoplasmic mitochondrial DNA by nucleoid-phagy. Nat Cell Biol 26, 849–850 (2024).

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