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Cell death

Lipidomes define immune cell identity

Diverse, specialized immune cells defend against pathogens and cancer cells. A new study reveals the comprehensive lipid compositions of these cells, with unique lipidomes associated with various immune cell types. They show that cell-specific lipid compositions determine a key functional phenotype: their susceptibility to ferroptosis.

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Fig. 1: Immune cells have distinct lipidomes which give rise to unique biophysical and biochemical properties and cellular functions.


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Correspondence to Kandice R. Levental or Whitney S. Henry.

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Levental, K.R., Henry, W.S. Lipidomes define immune cell identity. Nat Cell Biol 26, 516–518 (2024).

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