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Ironing out the details of ferroptosis

Abstract

Ferroptosis, spurred by excess labile iron and lipid peroxidation, is implicated in various diseases. Advances have been made in comprehending the lipid-peroxidation side of ferroptosis, but the exact role of iron in driving ferroptosis remains unknown. Although iron overload is characterized in multiple disease states, the potential role of ferroptosis within them remains undefined. This overview focuses on the ‘ferro’ side of ferroptosis, highlighting iron dysregulation in human diseases and potential therapeutic strategies targeting iron regulation and metabolism.

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Fig. 1: Biological functions of iron.
Fig. 2: Iron homeostasis regulation.
Fig. 3: Antioxidant enzymes in ferroptosis defence.

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Acknowledgements

This work was supported by a grant from the National Institutes of Health (R35ES031575).

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Zhang, D.D. Ironing out the details of ferroptosis. Nat Cell Biol 26, 1386–1393 (2024). https://doi.org/10.1038/s41556-024-01361-7

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