YTHDF family members are ‘readers’ of a common mRNA modification, but their effects on mRNA translation and stability have been disputed. A new study shows that YTHDF1 and YTHDF3 are post-translationally regulated through O-GlcNAcylation, unifying disparate results and pointing to environmental cues that could modulate YTHDF function.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
He, P. C. & He, C. EMBO J. 40, e105977 (2021).
Chen, Y. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01258-x (2023).
Slobodin, B. et al. Cell 169, 326–337.e312 (2017).
Meyer, K. D. et al. Cell 163, 999–1010 (2015).
Liu, J. et al. Nat. Cell Biol. 20, 1074–1083 (2018).
Wang, X. et al. Cell 161, 1388–1399 (2015).
Zaccara, S. & Jaffrey, S. R. Cell 181, 15821595.e1518 (2020).
Kontur, C., Jeong, M., Cifuentes, D. & Giraldez, A. J. Cell Rep. 33, 108598 (2020).
Zou, Z., Sepich-Poore, C., Zhou, X., Wei, J. & He, C. Genome Biol. 24, 17 (2023).
Darabedian, N., Thompson, J. W., Chuh, K. N., Hsieh-Wilson, L. C. & Pratt, M. R. Biochemistry 57, 5769–5774 (2018).
Gao, Y. et al. Cell Res. 29, 767–769 (2019).
Ries, R. J. et al. Nature 571, 424–428 (2019).
Fu, Y. & Zhuang, X. Nat. Chem. Biol. 16, 955–963 (2020).
Li, X., Pinou, L., Du, Y., Chen, X. & Liu, C. Curr. Opin. Chem. Biol. 75, 102314 (2023).
Yang, X. & Qian, K. Nat. Rev. Mol. Cell Biol. 18, 452–465 (2017).
We thank Y. Nam for comments on the manuscript.
The authors declare no competing interests.
About this article
Cite this article
Burns, M.W.N., Kohler, J.J. O-GlcNAc regulates YTHDF1 and YTHDF3 activity. Nat Cell Biol 25, 1570–1572 (2023). https://doi.org/10.1038/s41556-023-01275-w