Cells use various metabolic pathways to synthesize the building blocks for growth and proliferation. To ensure balanced growth, these biosynthetic processes must be tightly coordinated. We describe a molecular machinery that senses the cellular capacity to make lipids to regulate other biosynthetic processes — such as protein synthesis — accordingly.
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This is a summary of: Nicastro, R. et al. Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01198-6 (2023)
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Malonyl-CoA links lipid metabolism to nutrient signalling by directly inhibiting mTORC1. Nat Cell Biol 25, 1250–1251 (2023). https://doi.org/10.1038/s41556-023-01206-9