Pathways linked to the modification of RNA with N6-methyladenosine (m6A) are known to be involved in initiating and maintaining cancer. But many of the key components of these pathways remain undiscovered. The RBFOX2 protein has now been identified as an m6A reader involved in locus-specific chromatin regulation, with therapeutic implications for myeloid leukaemia.
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Barbieri, I. & Kouzarides, T. Nat. Rev. Cancer 20, 303–322 (2020).
Cheng, Y. et al. Cancer Cell 39, 958–972.e958 (2021).
Paris, J. et al. Cell Stem Cell 25, 137–148.e136 (2019).
Huang, H. et al. Nat. Cell Biol. 20, 285–295 (2018).
Zaccara, S. & Jaffrey, S. R. Cell 181, 1582–1595.e1518 (2020).
Zaccara, S., Ries, R. J. & Jaffrey, S. R. Nat. Rev. Mol. Cell Biol. 20, 608–624 (2019).
Dou, X. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01213-w (2023).
Barbieri, I. et al. Nature 552, 126–131 (2017).
Yankova, E. et al. Nature 593, 597–601 (2021).
Vu, L. P. et al. Nat. Med. 23, 1369–1376 (2017).
Liu, J. et al. Science 367, 580–586 (2020).
Tzelepis, K., Rausch, O. & Kouzarides, T. Nat. Struct. Mol. Biol. 26, 858–862 (2019).
Huang, H. et al. Nature 567, 414–419 (2019).
Hu, L. et al. Nat. Biotech. 40, 1210–1219 (2022).
Dick, J. E. Blood 112, 4793–4807 (2008).
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Russell, J., Tzelepis, K. A non-coding m6A reader promotes leukaemia. Nat Cell Biol 25, 1247–1249 (2023). https://doi.org/10.1038/s41556-023-01205-w