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Pausing pluripotency via RNA methylation

Embryonic diapause in development and paused pluripotency in embryonic stem cells result in a state of hypotranscription through mechanisms that remain unclear. A new study dissects the role of METTL3-deposited global m6A RNA methylation in mediating this transcriptional dormancy.

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Fig. 1: m6A modification of mRNA mediates hypotranscription during embryonic diapause.


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Correspondence to Baoming Qin.

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Xu, X., Qin, B. Pausing pluripotency via RNA methylation. Nat Cell Biol 25, 1241–1242 (2023).

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