Embryonic diapause in development and paused pluripotency in embryonic stem cells result in a state of hypotranscription through mechanisms that remain unclear. A new study dissects the role of METTL3-deposited global m6A RNA methylation in mediating this transcriptional dormancy.
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The authors declare no competing interests.
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Xu, X., Qin, B. Pausing pluripotency via RNA methylation. Nat Cell Biol 25, 1241–1242 (2023). https://doi.org/10.1038/s41556-023-01203-y