Lysosomes are catabolic organelles that govern numerous cellular processes, including macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in lysosome abundance are implicated in human diseases. Here we outline the mechanisms of lysosome biogenesis and turnover, and discuss how changes in the lysosome pool impact physiological and pathophysiological processes.
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We thank F. R. Maxfield and T. E. McGraw for helpful discussions. This work was supported by grants from the Swedish Research Council (grant no. 2020-01126), Swedish Cancer Society (grant nos 21 0437 JIA and 20 1188 Pj), Åke Wibergs Foundation, Lars Hierta’s Memory Foundation and Magnus Bergvall Foundation to A.P.M.; and National Institutes of Health grant no. R01 GM051405 to J.B. We apologize to those whose work was not included in this review due to limitations in scope and space.
The authors declare no competing interests.
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Mutvei, A.P., Nagiec, M.J. & Blenis, J. Balancing lysosome abundance in health and disease. Nat Cell Biol 25, 1254–1264 (2023). https://doi.org/10.1038/s41556-023-01197-7