In many species, a mother’s environment can impact offspring’s metabolism, but the mechanisms that mediate such intergenerational effects are unclear. In this issue, a study finds that the provisioning of a sphingolipid from mothers to offspring drives changes in offspring metabolism that protect against neuronal damage.
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The author declares no competing interests.
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Burton, N.O. A mother to offspring metabolic link. Nat Cell Biol 25, 1083–1084 (2023). https://doi.org/10.1038/s41556-023-01189-7