Class 3 phosphatidylinositol-3-kinase (PI3K) has a surprising nuclear function as a coactivator of the circadian clock Bmal1–Clock transcription factor complex for rhythmic purine nucleotide metabolism. This finding opens new avenues for establishing the roles of nuclear subunits of class 3 PI3K in metabolic homeostasis.
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This is a summary of: Alkhoury, C. et al. Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01171-3 (2023).
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Nuclear class 3 PI3K coactivates circadian clock. Nat Cell Biol 25, 933–934 (2023). https://doi.org/10.1038/s41556-023-01186-w
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DOI: https://doi.org/10.1038/s41556-023-01186-w
