A new study shows that the enzymes involved in de novo pyrimidine synthesis and ferroptosis form a complex called the pyrimidinosome, which is controlled by AMPK. Cancer cells low in AMPK expression rely on the pyrimidinosome, suggesting that co-inhibition of AMPK and the pyrimidinosome represents a potential cancer treatment strategy.
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References
Yang, C. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01146-4 (2023).
Jones, M. E. & Lipmann, F. J. Biol. Chem. 217, 361–371 (1955).
Rabinowitz, J. C. & Lipmann, F. J. Biol. Chem. 216, 727–736 (1955).
Weinberg, J. B. & Jones, M. E. J. Biol. Chem. 239, 2278–2286 (1964).
Jones, M. E. Annu. Rev. Biochem. 49, 253–279 (1980).
Loffler, M., Fairbanks, L. D., Zameitat, E., Marinaki, A. M. & Simmonds, H. A. Trends Mol. Med. 11, 430–437 (2005).
Wang, Y. et al. Nat. Commun. 10, 201 (2019).
Mao, C. et al. Nature 593, 586–590 (2021).
Dixon, S. J. et al. Cell 149, 1060–1072 (2012).
Stockwell, B. R. et al. Cell 171, 273–285 (2017).
Viswanathan, V. S. et al. Nature 547, 453–457 (2017).
Gao, M., Monian, P., Quadri, N., Ramasamy, R. & Jiang, X. Mol. Cell 59, 298–308 (2015).
Kagan, V. E. et al. Nat. Chem. Biol. 13, 81–90 (2017).
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Dodson, M., Zhang, D.D. The pyrimidinosome is cancer’s Achilles’ heel. Nat Cell Biol 25, 798–799 (2023). https://doi.org/10.1038/s41556-023-01159-z
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DOI: https://doi.org/10.1038/s41556-023-01159-z
