Desmosomes and keratin are now found to regulate the distribution and dynamics of the endoplasmic reticulum (ER). This suggests that a range of ER functions may be coordinated by this intercellular adhesive and cytoskeletal network.
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Westrate, L. M. et al. Annu. Rev. Biochem. 84, 791–811 (2015).
Bharathan, N. K. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01154-4 (2023).
Farquhar, M. G. & Palade, G. E. J. Cell Biol. 17, 375–412 (1963).
Badu-Nkansah, K. A. & Lechler, T. Mol. Biol. Cell 31, 1140–1153 (2020).
Fey, E. G. et al. J. Cell Biol. 98, 1973–1984 (1984).
Pasdar, M. et al. J. Cell Biol. 113, 645–655 (1991).
Hobbs, R. P. et al. FASEB J. 25, 990–1001 (2011).
Chacon-Camacho, O. F. et al. Am. J. Med. Genet. A 182, 2773–2777 (2020).
Morice-Picard, F. et al. J. Invest. Dermatol. 140, 1289–1292 (2020).
Wu, J. & Kaufman, R. J. Cell Death Differ. 13, 374–384 (2006).
Costa-Mattioli, M. & Walter, P. Science 368, eaat5314 (2020).
Poncet, N. et al. EMBO Rep. 21, e48469 (2020).
Sugiura, K. et al. J. Invest. Dermatol. 129, 2126–2135 (2009).
Ishida-Yamamoto, A. et al. J. Dermatol. 38, 645–654 (2011).
Watanabe, S. et al. Proc. Natl Acad. Sci. USA 118, e2101100118 (2021).
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Harmon, R.M., Gottardi, C.J. Endoplasmic reticulum tethering by desmosomes. Nat Cell Biol 25, 796–797 (2023). https://doi.org/10.1038/s41556-023-01144-6