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Organoids

A guide from the stomach to β cells

Direct conversions offer an alternative approach to generate insulin-producing cells for cell therapy in diabetes. A study reports a method to convert human stomach-derived gastric stem cells into functional insulin-producing cells through a unique differentiation path.

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Fig. 1: Character of GINS organoids.

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J.C. and F.C. contributed equally to this work.

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Correspondence to Eiji Yoshihara.

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The authors declare no competing interests.

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Choi, J., Cayabyab, F. & Yoshihara, E. A guide from the stomach to β cells. Nat Cell Biol 25, 637–638 (2023). https://doi.org/10.1038/s41556-023-01140-w

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