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Endoplasmic reticulum-associated degradation shown to regulate innate immunity

The SEL1L–HRD1 endoplasmic reticulum-associated degradation pathway negatively regulates STING-mediated innate immunity by ubiquitinating and targeting STING for proteasomal degradation, thereby limiting its activation.

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Fig. 1: SEL1L–HRD1 ERAD negatively regulates the activable STING pool size in macrophages.


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This is a summary of: Ji, Y. et al. SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool. Nat. Cell Biol. (2023).

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Endoplasmic reticulum-associated degradation shown to regulate innate immunity. Nat Cell Biol 25, 641–642 (2023).

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