Using single-cell transcriptomics and functional assays, we identified various subsets of pancreatic beta cells. One subset, characterized by high levels of CD63, demonstrated enhanced glucose metabolism, mitochondrial activity, and glucose-induced insulin secretion, and the proportion of these beta cells was decreased in mouse models of type 2 diabetes (T2D) and humans with T2D.
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This is a summary of: Rubio-Navarro, A. et al. A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01103-1 (2023).
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Perturbations in beta-cell heterogeneity in the pathogenesis of type 2 diabetes. Nat Cell Biol 25, 524–525 (2023). https://doi.org/10.1038/s41556-023-01105-z