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Cell death

Deadly actin collapse by disulfidptosis

Programmed cell death (PCD) enables cells to co-ordinate their exit to benefit the surviving organism. A new study describes how cells can programme their death by inducing extensive disulfide bonding of the actin cytoskeleton in response to an imbalance of cystine, a raw material for glutathione production.

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Fig. 1: Schematic of how glucose starvation in SLC7A11high cells causes death by disulfidptosis.

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Correspondence to Laura M. Machesky.

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Machesky, L.M. Deadly actin collapse by disulfidptosis. Nat Cell Biol 25, 375–376 (2023). https://doi.org/10.1038/s41556-023-01100-4

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