Activation of a crucial immune adaptor protein, STING, is tightly regulated by subcellular trafficking, but how it is deactivated remains less well defined. A study now shows that ESCRT-dependent encapsulation of STING-carrying vesicles by lysosomal compartments — through the process of microautophagy — mediates the termination of STING signalling.
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Chen, C. & Xu, P. Trends Cell Biol. https://doi.org/10.1016/j.tcb.2022.11.001 (2022).
Zhang, B. C. et al. Nat. Immunol. 21, 868–879 (2020).
Gonugunta, V. K. et al. Cell Rep. 21, 3234–3242 (2017).
Liu, Y. et al. Nature 610, 761–767 (2022).
Kuchitsu, Y. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01098-9 (2023).
Prabakaran, T. et al. EMBO J. 37, e97858 (2018).
Gui, X. et al. Nature 567, 262–266 (2019).
Liu, D. et al. Cell Death Diff. 26, 1735–1749 (2019).
Horner, D. S. et al. Semin. Cell. Dev. Biol. 74, 29–39 (2018).
Gentili, M. et al. Preprint at bioRxiv https://doi.org/10.1101/2022.09.22.509044 (2022).
Nandakumar, R. et al. Nat. Microbiol. 4, 701 (2019).
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Assil, S., Paludan, S.R. STING is ESCRTed to degradation by microautophagy. Nat Cell Biol 25, 379–380 (2023). https://doi.org/10.1038/s41556-022-01084-7