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STING is ESCRTed to degradation by microautophagy

Activation of a crucial immune adaptor protein, STING, is tightly regulated by subcellular trafficking, but how it is deactivated remains less well defined. A study now shows that ESCRT-dependent encapsulation of STING-carrying vesicles by lysosomal compartments — through the process of microautophagy — mediates the termination of STING signalling.

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Fig. 1: Degradation of STING by ESCRT-mediated microautophagy.


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Correspondence to Søren R. Paludan.

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Assil, S., Paludan, S.R. STING is ESCRTed to degradation by microautophagy. Nat Cell Biol 25, 379–380 (2023).

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