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Phase separation

+TIPs condense on microtubule plus-ends

End-binding proteins attach to the dynamic plus-ends of microtubules in order to regulate microtubule polymerization and the transport of other plus-end tracking proteins (+TIPs). Three new studies dissect the multivalent interactions that constitute distinct +TIP networks and reveal that they give rise to liquid-like biomolecular condensates.

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Fig. 1: Condensates of plus-end tracking proteins on microtubules.


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Correspondence to Sabine Petry.

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Gouveia, B., Petry, S. +TIPs condense on microtubule plus-ends. Nat Cell Biol 25, 12–14 (2023).

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