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Epigenetics

Oncogenic role for an EWS–FLI1 suppressor

Nature Cell Biology volume 25, pages 214–216 (2023)Cite this article

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Tight regulation of the activity of EWS–ETS fusion proteins is essential for the growth of Ewing sarcomas. Two new studies show that the transcriptional repressor ETV6 is essential for tumour growth, acting to restrain fusion-protein-mediated gene activation, and revealing the importance of tissue-specific transcription factors to oncogenesis.

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Fig. 1: ETV6 acts to transcriptionally constrain EWS–FLI1 activity.

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  1. Seattle Children’s Research Institute, Seattle, WA, USA

    April A. Apfelbaum & Elizabeth R. Lawlor

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  1. April A. Apfelbaum
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  2. Elizabeth R. Lawlor
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Correspondence to Elizabeth R. Lawlor.

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The authors declare no competing interests.

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Apfelbaum, A.A., Lawlor, E.R. Oncogenic role for an EWS–FLI1 suppressor. Nat Cell Biol 25, 214–216 (2023). https://doi.org/10.1038/s41556-022-01067-8

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