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A guide to naming eukaryotic circular RNAs

Alternative splicing of eukaryotic messenger RNA transcripts often leads to the production of several mature RNAs — including linear RNAs and circular RNAs (circRNAs) — from a single gene locus. The names given to circRNAs are often ambiguous and lack consistency across studies. This Comment calls on the community to embrace a common nomenclature for naming circRNAs to ensure clarity and reproducibility.

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Fig. 1: Suggested naming scheme to clarify the complexity of patterns of expression of circRNAs.


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Correspondence to Ling-Ling Chen, Jeremy E. Wilusz or Li Yang.

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J.E.W. is a consultant for Laronde. H.Y.C. is a co-founder of Orbital Therapeutics. The other authors declare no competing interests.

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Nature Cell Biology thanks Igor Ulitsky, Shenglin Huang, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Chen, LL., Bindereif, A., Bozzoni, I. et al. A guide to naming eukaryotic circular RNAs. Nat Cell Biol 25, 1–5 (2023).

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