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Stem cells

A seed-and-soil theory for blood ageing

The bone marrow is the daily production site for hundreds of billions of blood cells. A new study adds evidence that, during ageing, signals emanating from bone-marrow stromal cells shift to produce inflammatory factors that skew blood-cell output, driving age-related tissue deterioration.

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Fig. 1: Ageing of the stromal niche in the bone marrow affects the output of blood stem cells.


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Correspondence to Charles K. F. Chan.

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Ambrosi, T.H., Chan, C.K.F. A seed-and-soil theory for blood ageing. Nat Cell Biol 25, 9–11 (2023).

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