The bone marrow is the daily production site for hundreds of billions of blood cells. A new study adds evidence that, during ageing, signals emanating from bone-marrow stromal cells shift to produce inflammatory factors that skew blood-cell output, driving age-related tissue deterioration.
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The authors declare no competing interests.
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Ambrosi, T.H., Chan, C.K.F. A seed-and-soil theory for blood ageing. Nat Cell Biol 25, 9–11 (2023). https://doi.org/10.1038/s41556-022-01062-z