Extramitochondrial coenzyme Q (CoQ) can function as a potent anti-ferroptosis radical trapper. However, it is largely unknown how CoQ is transported from mitochondria to the plasma membrane. A study now suggests that PARL-mediated STARD7 processing is responsible for the cellular distribution of CoQ.
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D.L. is an inventor of a patent relevant to autophagy. X.J. is an inventor of patents relevant to cell death and autophagy. He is also a consultant and equity holder of Exarta Therapeutics and Lime Therapeutics.
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Liang, D., Jiang, X. START smuggling CoQ to fight ferroptosis. Nat Cell Biol 25, 207–208 (2023). https://doi.org/10.1038/s41556-022-01044-1