Tumour-initiating cells are resistant to challenging growth conditions during the initiation of pancreatic cancer, but how transformed cells acquire a stress-resistant, tumour-initiating state remains unclear. Here, the authors identify a signalling cascade in which LPAR4 induces fibronectin production, cancer stemness and a tumour-initiating niche.
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Arnold, F., Sherman, M.H. LPAR4 establishes a tumour-initiating niche. Nat Cell Biol 25, 217–219 (2023). https://doi.org/10.1038/s41556-022-01038-z
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DOI: https://doi.org/10.1038/s41556-022-01038-z
