Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Stem cells

Splitting up differentiation and cell cycle exit

The onset of differentiation has been assumed to follow withdrawal from the cell cycle. A new study shows that keratinocytes initiate differentiation before exiting the cell cycle, allowing the skin to respond rapidly to damage.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Proposed model of epidermal basal cell differentiation and the contribution of Krt10 and Krt10+ basal cells to tissue homeostasis.

References

  1. Piedrafita, G. et al. Nat. Commun. 11, 1429 (2020).

    Article  CAS  Google Scholar 

  2. Cockburn, K. et al. Nat. Cell Biol. https://doi.org/s41556-022-01021-8 (2022).

  3. Mascre, G. et al. Nature 489, 257–262 (2012).

    Article  CAS  Google Scholar 

  4. Doupe, D. P., Klein, A. M., Simons, B. D. & Jones, P. H. Dev. Cell 18, 317–323 (2010).

    Article  CAS  Google Scholar 

  5. Kim, D. S. et al. Nat. Genet. 53, 1564–1576 (2021).

    Article  CAS  Google Scholar 

  6. Mesa, K. R. et al. Cell Stem Cell 23, 677–686.e674 (2018).

    Article  CAS  Google Scholar 

  7. Park, S. et al. Nat. Cell Biol. 19, 155–163 (2017).

    Article  CAS  Google Scholar 

  8. Doupe, D. P. et al. Science 337, 1091–1093 (2012).

    Article  CAS  Google Scholar 

  9. Jones, K. et al. Cell Stem Cell 24, 183–192.e188 (2019).

    Article  CAS  Google Scholar 

  10. McGinn, J. et al. Nat. Cell Biol. 23, 511–525 (2021).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

P.H.J. is supported by Wellcome Trust funding to the Sanger Institute (296194) and a Cancer Research UK Programme Grant (C609/A27326). A.H. is supported by a Maria Zambrano Grant to attract international talent from the Universitat de Barcelona and Ministerio de Universidades and co-funded with Next Generation EU funds.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Philip H. Jones.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Herms, A., Jones, P.H. Splitting up differentiation and cell cycle exit. Nat Cell Biol 24, 1687–1688 (2022). https://doi.org/10.1038/s41556-022-01022-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-022-01022-7

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing