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Stem cells

Splitting up differentiation and cell cycle exit

The onset of differentiation has been assumed to follow withdrawal from the cell cycle. A new study shows that keratinocytes initiate differentiation before exiting the cell cycle, allowing the skin to respond rapidly to damage.

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Fig. 1: Proposed model of epidermal basal cell differentiation and the contribution of Krt10 and Krt10+ basal cells to tissue homeostasis.


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P.H.J. is supported by Wellcome Trust funding to the Sanger Institute (296194) and a Cancer Research UK Programme Grant (C609/A27326). A.H. is supported by a Maria Zambrano Grant to attract international talent from the Universitat de Barcelona and Ministerio de Universidades and co-funded with Next Generation EU funds.

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Correspondence to Philip H. Jones.

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Herms, A., Jones, P.H. Splitting up differentiation and cell cycle exit. Nat Cell Biol 24, 1687–1688 (2022).

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