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Stem cells

Splitting up differentiation and cell cycle exit

Nature Cell Biology volume 24, pages 1687–1688 (2022)Cite this article

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The onset of differentiation has been assumed to follow withdrawal from the cell cycle. A new study shows that keratinocytes initiate differentiation before exiting the cell cycle, allowing the skin to respond rapidly to damage.

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Fig. 1: Proposed model of epidermal basal cell differentiation and the contribution of Krt10– and Krt10+ basal cells to tissue homeostasis.

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Acknowledgements

P.H.J. is supported by Wellcome Trust funding to the Sanger Institute (296194) and a Cancer Research UK Programme Grant (C609/A27326). A.H. is supported by a Maria Zambrano Grant to attract international talent from the Universitat de Barcelona and Ministerio de Universidades and co-funded with Next Generation EU funds.

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Authors and Affiliations

  1. Department of Biomedical Sciences, Faculty of Medicine, Universitat de Barcelona, Barcelona, Spain

    Albert Herms

  2. Cell Compartments and Signalling Group, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

    Albert Herms

  3. Wellcome Sanger Institute, Hinxton, UK

    Philip H. Jones

  4. Department of Oncology, University of Cambridge, Hutchison Research Centre, Cambridge Biomedical Campus, Cambridge, UK

    Philip H. Jones

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  1. Albert Herms
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  2. Philip H. Jones
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Correspondence to Philip H. Jones.

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The authors declare no competing interests.

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Herms, A., Jones, P.H. Splitting up differentiation and cell cycle exit. Nat Cell Biol 24, 1687–1688 (2022). https://doi.org/10.1038/s41556-022-01022-7

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