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Immunology

Telomeres are a life-extending gift

Cellular senescence induced by DNA replication and telomere attrition contributes to organ dysfunction, inflammation and impaired immunity. A study reveals that antigen-presenting cells provide telomeric DNA to CD4+ T cells in synaptic contact, which enables the suspension of senescence, T cell expansion and long-lived immunity.

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Fig. 1: APC donation of telomeres to T cells suppresses senescence and promotes long-term immunity.

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Correspondence to Christina Camell.

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Carey, A., Niedernhofer, L. & Camell, C. Telomeres are a life-extending gift. Nat Cell Biol 24, 1449–1450 (2022). https://doi.org/10.1038/s41556-022-01004-9

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  • DOI: https://doi.org/10.1038/s41556-022-01004-9

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