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Ribosome specialization in glioblastoma

Specialized activities of ribosomal components that regulate the expression of specific genes is an emerging field of research. A new study identifies alternative splicing of a ribosomal protein between the peripheral and core regions of glioblastoma tumours to produce isoforms with distinct functions.

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Fig. 1: Glioblastoma tumours have localized expression of ribosomal protein isoforms, leading to gene expression programs that are distinct between the tumour periphery and the core.


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Correspondence to Maria Barna.

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Genuth, N.R., Barna, M. Ribosome specialization in glioblastoma. Nat Cell Biol 24, 1451–1453 (2022).

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