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Cancer

Ribosome specialization in glioblastoma

Specialized activities of ribosomal components that regulate the expression of specific genes is an emerging field of research. A new study identifies alternative splicing of a ribosomal protein between the peripheral and core regions of glioblastoma tumours to produce isoforms with distinct functions.

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Fig. 1: Glioblastoma tumours have localized expression of ribosomal protein isoforms, leading to gene expression programs that are distinct between the tumour periphery and the core.

References

  1. Larionova, T. D. Nat. Cell Biol. https://doi.org/10.1038/s41556-022-00994-w (2022).

    Article  PubMed  Google Scholar 

  2. Shi, Z. Mol. Cell 67, 71–83 (2017).

    Article  CAS  Google Scholar 

  3. van de Waterbeemd, M. Nat. Commun. 9, 2493 (2018).

    Article  Google Scholar 

  4. Brumwell, A., Fell, L., Obress, L. & Uniacke, J. RNA 26, 361–371 (2020).

    Article  CAS  Google Scholar 

  5. Gupta, V. & Warner, J. R. RNA 20, 1004–1013 (2014).

    Article  CAS  Google Scholar 

  6. O’Leary, M. N. PLoS Genet. 9, e1003708 (2013).

    Article  Google Scholar 

  7. Anderson, S. J. Immunity 26, 759–772 (2007).

    Article  CAS  Google Scholar 

  8. Zhang, Y. Cell Rep. 18, 545–556 (2017).

    Article  CAS  Google Scholar 

  9. Fahl, S. P. J. Immunol. 208, 870–880 (2022).

    Article  CAS  Google Scholar 

  10. Solanki, N. R. J. Immunol. 197, 2280–2289 (2016).

    Article  CAS  Google Scholar 

  11. Sulima, S. O., Hofman, I. J. F., De Keersmaecker, K. & Dinman, J. D. Cancer Discov. 7, 1069–1087 (2017).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Maria Barna.

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Genuth, N.R., Barna, M. Ribosome specialization in glioblastoma. Nat Cell Biol 24, 1451–1453 (2022). https://doi.org/10.1038/s41556-022-01000-z

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