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Cancer

Metabolic phosphatase moonlights for proteins

In tumours, cancer cells can overcome energy stress via differential regulation of non-canonical ‘moonlighting’ functions of metabolic enzymes. A study now shows that the metabolic phosphatase fructose-1,6-bisphosphatase 1 (FBP1) can act as a nuclear protein phosphatase and reveals how this process is inhibited in cancer cells.

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Fig. 1: Energy-stress-induced FBP1 signaling in normal hepatocytes and hepatocellular carcinoma cells.

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Correspondence to Arminja N. Kettenbach.

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Gerber, S.A., Kettenbach, A.N. Metabolic phosphatase moonlights for proteins. Nat Cell Biol 24, 1568–1570 (2022). https://doi.org/10.1038/s41556-022-00993-x

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