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Finding a chaperone for TDP-43

Aggregation of the RNA-binding protein TDP-43 is commonly observed in neurodegenerative disorders. A new study reveals that this process may be blocked by HSPB1, a small heat shock protein that can also regulate TDP-43 phase separation. This may be relevant to neurodegeneration, as loss of HSPB1 correlates with TDP-43 pathology.

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Fig. 1: HSPB1 recruitment to TDP-43 condensates maintains dynamic properties under proteotoxic stress.


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Correspondence to Yuna M. Ayala.

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Ayala, Y.M., Grese, Z.R. Finding a chaperone for TDP-43. Nat Cell Biol 24, 1328–1330 (2022).

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