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METABOLISM

Keeping up with the Rag GTPases

The Rag GTPases form the link between extracellular nutrients and the activation of mTORC1. RagA/B and RagC/D have been considered functionally redundant, but two studies now show that each isoform and gene have specific features, making their control of mTORC1 activity more nuanced and complex than previously appreciated.

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Fig. 1: Unique structure, regulation, and functions of the Rag GTPases.

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Correspondence to Elizabeth P. Henske.

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Alesi, N., Henske, E.P. Keeping up with the Rag GTPases. Nat Cell Biol 24, 1330–1331 (2022). https://doi.org/10.1038/s41556-022-00981-1

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