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Keeping up with the Rag GTPases

The Rag GTPases form the link between extracellular nutrients and the activation of mTORC1. RagA/B and RagC/D have been considered functionally redundant, but two studies now show that each isoform and gene have specific features, making their control of mTORC1 activity more nuanced and complex than previously appreciated.

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Fig. 1: Unique structure, regulation, and functions of the Rag GTPases.


  1. Sancak, Y. et al. Science 320, 1496–1501 (2008).

    Article  CAS  Google Scholar 

  2. Shen, K. et al. Nature 556, 64–69 (2018).

    Article  CAS  Google Scholar 

  3. Petit, C. S., Roczniak-Ferguson, A. & Ferguson, S. M. J. Cell Biol. 202, 1107–1122 (2013).

    Article  CAS  Google Scholar 

  4. Li, K. et al. PLoS Biol. 20, e3001594 (2022).

    Article  CAS  Google Scholar 

  5. Demetriades, C., Doumpas, N. & Teleman, A. A. Cell 156, 786–799 (2014).

    Article  CAS  Google Scholar 

  6. Figlia, G. et al. Nat. Cell Biol. (2022).

  7. Gollwitzer, P., Grutzmacher, N., Wilhelm, S., Kummel, D. & Demetriades, C. Nat. Cell Biol. (2022).

  8. Napolitano, G. et al. Nature 585, 597–602 (2020).

    Article  CAS  Google Scholar 

  9. Gosis, B. S. et al. Science 376, eabf8271 (2022).

    Article  CAS  Google Scholar 

  10. Alesi, N. et al. Nat. Commun. 12, 4245 (2021).

    Article  CAS  Google Scholar 

  11. Di Malta, C. et al. Science 356, 1188–1192 (2017).

    Article  Google Scholar 

  12. Yang, S. et al. Dev. Cell 55, 272–288.e5 (2020).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Elizabeth P. Henske.

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Alesi, N., Henske, E.P. Keeping up with the Rag GTPases. Nat Cell Biol 24, 1330–1331 (2022).

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