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Localization-dictated function for METTL3

Aberrant subcellular localization of proteins contributes to the pathogenesis of cancer. A study now reports that the mis-localization of METTL3, a nuclear N6-adenosine methyltransferase, to the cytoplasm promotes gastric cancer by enhancing mRNA translation of a subset of oncogenes, independently of the N6-methyladenosine (m6A) modification.

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Fig. 1: METTL3 has different functions depending on its subcellular location in gastric cancer.


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Correspondence to Michaela Frye.

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M.F. receives commercial funding from MERCK. S.D. declares no competing interests.

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Delaunay, S., Frye, M. Localization-dictated function for METTL3. Nat Cell Biol 24, 1188–1189 (2022).

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