Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

CANCER

EGFR ligands dictate tumour suppression

Nature Cell Biology volume 24, pages 1189–1191 (2022)Cite this article

Subjects

EGFR is an oncogene that is frequently amplified in glioblastoma. A new study suggests a tumour-suppressive role of EGFR in EGFR-amplified glioblastoma regulated by ligand abundance. Increased EGFR ligand in EGFR-amplified glioblastoma suppresses invasion by upregulating BIN3 and inhibiting activation of Rho GTPases.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: EGFR directs two distinct and mutually exclusive signalling pathways: constitutive signalling and ligand-activated signalling.

References

  1. Louis, D. N. et al. Neuro Oncol. 23, 1231–1251 (2021).

    Article  CAS  Google Scholar 

  2. Dirks, P. B. et al. Clin. Cancer Res. 26, 2457–2460 (2020).

    Article  Google Scholar 

  3. Brennan, C. W. et al. Cell 155, 462–477 (2013).

    Article  CAS  Google Scholar 

  4. Fan, Q. W. et al. Cancer Cell 24, 438–449 (2013).

    Article  CAS  Google Scholar 

  5. Chakraborty, S. et al. Nat. Commun. 5, 5811 (2014).

    Article  CAS  Google Scholar 

  6. Singh, B. et al. F1000 Res. https://doi.org/10.12688/f1000research.9025.1 (2016).

    Article  Google Scholar 

  7. Hu, C. et al. Nature 602, 518–522 (2022).

    Article  CAS  Google Scholar 

  8. Guo, G. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-022-00962-4 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  9. An, Z. et al. Oncogene 37, 1561–1575 (2018).

    Article  CAS  Google Scholar 

  10. de Vries, N. A. et al. Invest. New Drugs 30, 443–449 (2012).

    Article  CAS  Google Scholar 

  11. Barkovich, K. J. et al. Cancer Discov. 2, 450–457 (2012).

    Article  CAS  Google Scholar 

  12. Ramnarain, D. B. et al. Cancer Res. 66, 867–874 (2006).

    Article  CAS  Google Scholar 

  13. Prendergast, G. C. et al. Biochim. Biophys. Acta 1796, 25–36 (2009).

    Google Scholar 

  14. Murray, D. W. et al. Br. J. Cancer 110, 1307–1315 (2014).

    Article  CAS  Google Scholar 

  15. Ramnarain, D. B. et al. Cancer Res. 66, 867–874 (2006).

    Article  CAS  Google Scholar 

  16. Le Rhun, E. et al. Cancer Treat. Rev. 80, 101896 (2019).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Scientist Training Program and Graduate Program in Biomedical Sciences, University of California, San Francisco, CA, USA

    Mary Clare Beytagh & William A. Weiss

  2. Department of Neurology, University of California, San Francisco, CA, USA

    William A. Weiss

  3. Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA

    William A. Weiss

  4. Departments of Pediatrics and Neurological Surgery, University of California, San Francisco, CA, USA

    William A. Weiss

Authors
  1. Mary Clare Beytagh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. William A. Weiss
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to William A. Weiss.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Beytagh, M.C., Weiss, W.A. EGFR ligands dictate tumour suppression. Nat Cell Biol 24, 1189–1191 (2022). https://doi.org/10.1038/s41556-022-00967-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-022-00967-z

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer