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Navigating ferroptosis via an NADPH sensor

NADPH levels serve as a biomarker of sensitivity to ferroptosis, but the regulators that detect cellular NADPH levels and modulate downstream ferroptosis responses are unknown. A study now identifies MARCHF6 in the ubiquitin system as an NADPH sensor that suppresses ferroptosis.

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Fig. 1: Model depicting how MARCHF6 coordinates cellular NADPH levels with ferroptosis response.


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Correspondence to Boyi Gan.

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Competing interests

B.G. is an inventor on patent applications involving targeting ferroptosis in cancer therapy. C.M. declares no competing interests.

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Mao, C., Gan, B. Navigating ferroptosis via an NADPH sensor. Nat Cell Biol 24, 1186–1187 (2022).

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