NADPH levels serve as a biomarker of sensitivity to ferroptosis, but the regulators that detect cellular NADPH levels and modulate downstream ferroptosis responses are unknown. A study now identifies MARCHF6 in the ubiquitin system as an NADPH sensor that suppresses ferroptosis.
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B.G. is an inventor on patent applications involving targeting ferroptosis in cancer therapy. C.M. declares no competing interests.
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Mao, C., Gan, B. Navigating ferroptosis via an NADPH sensor. Nat Cell Biol 24, 1186–1187 (2022). https://doi.org/10.1038/s41556-022-00963-3
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DOI: https://doi.org/10.1038/s41556-022-00963-3
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